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Invitrogen™ PANK2 Monoclonal Antibody (OTI3H9)
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Catalog No. PIMA525152
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100 μL
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PIMA525152 100 μL
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Catalog No. PIMA525152 Supplier Invitrogen™ Supplier No. MA525152
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Description

Mouse Monoclonal Antibody

PANK2 Monoclonal Antibody for Western Blot, ICC/IF, IHC (P), Flow

Pantothenate kinase is an essential regulatory enzyme in CoA biosynthesis, catalyzing the cytosolic phosphorylation of pantothenate (vitamin B5), N-pantothenoylcysteine, and pantetheine. CoA is the major acyl carrier, playing a central role in intermediary and fatty acid metabolism. In both yeast and fly, each with only 1 pantothenate kinase gene, the null mutant is inviable. Mutations in PANK2 are the cause of pantothenate kinase-associated neurodegeneration (PKAN), formerly known as Hallervorden-Spatz syndrome (HSS). PKAN is an autosomal recessive neurodegenerative disorder associated with iron accumulation in the brain. Mutations in PANK2 are the cause of hypoprebetalipoproteinemia, acanthocytosis, retinitis pigmentosa, and pallidal degeneration (HARP).
TRUSTED_SUSTAINABILITY

Specifications

Antigen PANK2
Applications Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Monoclonal
Clone OTI3H9
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene PANK2
Gene Accession No. Q9BZ23
Gene Alias 4933409I19Rik; AI642621; C20orf48; Hallervorden-Spatz syndrome; HARP; hPanK2; HSS; NBIA1; PANK2; pantothenate kinase 2; pantothenate kinase 2 (Hallervorden-Spatz syndrome); pantothenate kinase 2, mitochondrial; pantothenate kinase 2, mitochondrial isoform 1 preproprotein; pantothenate kinase 2, mitochondrial-like; pantothenic acid kinase 2; PKAN
Gene Symbols PANK2
Host Species Mouse
Immunogen Full length human recombinant protein of PANK2 produced in HEK293T cell.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 296167, 477168, 80025
Target Species Human, Rat, Canine, Monkey
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG2a
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