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Invitrogen™ Pannexin 2 Polyclonal Antibody
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Catalog No. 422900
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42-290-0 100 μg
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Catalog No. 42-290-0 Supplier Invitrogen™ Supplier No. 422900
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Description

Rabbit Polyclonal Antibody

Pannexin 2 Polyclonal Antibody for Western Blot, ICC/IF, IHC (P)

Gap junctions are channel-forming structures that allow direct metabolic and electrical communication between adjacent cells of almost all types in mammalian tissues. In the human body, they are absent only in adult skeletal muscle cells and some circulating blood cells. A gap junction is formed two hemichannels, one in each of the neighboring cells, composed of six subunits. In mice and humans, at least 20 connexin and 3 pannexin genes encode gap junction proteins. Connexins are only found in chordates, while pannexins are present in both chordate and invertebrate genomes. Pannexins, previously known as innexins, are predicted to have four transmembrane regions, two extracellular loops, one intracellular loop, and intracellular N- and C-termini. Both human and mouse genomes contain three pannexin-encoded genes. Pannexin 2 (Px2, PANX2) appears to be a brain specific gene, and is abundantly expressed in the central nervous system, as is pannexin 1. In many neuronal cell populations, including hippocampus, olfactory bulb, cortex, and cerebellum, pannexin 1 and pannexin 2 are co-expressed; in other brain regions such as white matter, only pannexin 1-positive cells are found.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Pannexin 2
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.25 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.1% sodium azide; pH 7.4
Gene PANX2
Gene Accession No. P60571, Q6IMP4, Q96RD6
Gene Alias h PX2; hPANX2; pannexin 2; pannexin-2; PANX2; Px2; si:ch211-192n14.2
Gene Symbols PANX2
Host Species Rabbit
Immunogen Synthetic peptide derived from an internal region of human, mouse, and rat pannexin 2, which is identical to predicted bovine and dog sequence.
Purification Method Antigen Affinity Chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 362979, 406218, 56666
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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