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CPC Scientific H-Phe-Ser-Leu-Leu-Arg-Tyr-NH2 (trifluoroacetate salt) 25MG
Supplier: CPC Scientific PARP004B
This peptide inhibited activation of PAR-2 by trypsin in PAR-2 receptor expressing KNRK cells. Half-maximal inhibition of calcium signaling was observed at about 50 ?M. In contrast, the activation of PAR-2 by SLIGRL-NH2 (PAR-2 (1-6) amide (mouse, rat)) was not inhibited by this peptide. Selective Antagonist for PAR2 Agonist. This peptide blocks trypsin but not SLIGRL-NH2 activation of PAR2 in receptor-expressing KNRK cells.SEQUENCE: H-Phe-Ser-Leu-Leu-Arg-Tyr-NH2 (trifluoroacetate salt)ONE-LETTER SEQUENCE: FSLLRY-NH2MOLECULAR FORMULA: C39H60N10O8MOLECULAR WEIGHT: 796.97STORAGE CONDITIONS: -20 5 CCAS REGISTRY NUMBER: [245329-02-6]SYNONYMS: RESEARCH AREA: HematologyREFERENCES:B.Al-Ani et al., J. Pharmacol. Exp. Ther., 300, 702 (2002)S.Wilson et al., Biochem. J., 388, 967 (2005)SKU(s): PARP-004A, PARP-004B
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