Invitrogen™ Human PON1 Recombinant Protein

Description

Recombinant Protein

This product contains purified recombinant human Paraoxonase 1 protein with an N-terminal hexahistidine tag. This product may be used as a positive control in many immunological assays.

The paraoxonase (PON) gene-family in humans has three members, PON1, PON2, and PON3, aligned next to each other on the long arm of chromosome 7q21.3-22.1. PON1 of these is synthesized primarily in the liver and a portion is secreted into the plasma, where it is associated with high density lipoproteins (HDL). And It hydrolyzes the active metabolites of several other organophosphorus insecticides (e.g., chlorpyrifos oxon, diazoxon), as well as nerve agents such as sarin, soman and VX (lethal nerve agent). The PON1 polymorphism may be responsible for neurodegeneration and considered to be an independent risk factor for Parkinson's disease.

Specifications

• Accession Number: P27169
• Concentration: 0.69 mg/mL
• For Use With (Application): Control, Western Blot
• Formulation: 20 mM tris HCl with 50% glycerol and no preservative; pH 8
• Gene ID (Entrez): 5444
• Molecular Weight (g/mol): 44.26 kDa
• Name: Human PON1
• Quantity: 100 μg
• Source: E. Coli
• Regulatory Status: RUO
• Gene Alias: 2810004E20; 6330405I24Rik; A esterase 1; A-esterase 1; A-esterase 2; AI481612; AI786302; Aromatic esterase 1; aromatic esterase 2; arylesterase 1; arylesterase 2; arylesterase 3; arylesterase B-type; EC 3.1.1.2; EC 3.1.1.81; EC 3.1.8.1; ESA; ESAesterase A; esterase A; K-45; MVCD5; paraoxanase-3; paraoxonase 1; paraoxonase 2; paraoxonase 3; paraoxonase B-type; paraoxonase nirs; PON; PON 1; PON 2; Pon1; PON2; PON3; serum aryldiakylphosphatase; serum aryldialkylphosphatase 1; Serum aryldialkylphosphatase 2; serum paraoxonase/arylesterase 1; Serum paraoxonase/arylesterase 2; serum paraoxonase/lactonase 3
• Common Name: PON1
• Gene Symbol: PON1
• Conjugate: Unconjugated
• Species: E. coli
• Recombinant: Recombinant
• Protein Tag: His-tag
• Sequence: Amino acids Met1- Leu355 containing an N-terminal His-tag
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Expression System: E. coli
• Form: Liquid
• Protein Subtype: Recombinant
• Purity or Quality Grade: >95%, by SDS-PAGE under reducing conditions

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov