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Invitrogen™ Parvalbumin Monoclonal Antibody (C12), FITC
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Catalog No. PIMA545928
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100 μg
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Catalog No. Quantity
PIMA545928 100 μg
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Catalog No. PIMA545928 Supplier Invitrogen™ Supplier No. MA545928
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Description

Mouse Monoclonal Antibody

A 1:500 dilution of MA5-45928 was sufficient for detection of Parvalbumin in 15 μg of Rat Brain by ECL immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody. Detects 12 kDa.

Parvalbumin (PV) is a calcium binding protein expressed in specific muscle fibers and fast-firing neurons. PV consists of a single, unbranched chain of linked amino acids and belongs to a larger group of EF hand proteins. Studies have demonstrated that parvalbumin acts in the decay of calcium in the contraction/ relaxation cycle of fast twitch muscles. This data has shown a positive correlation between the rate of relaxation and the concentration of parvalbumin. Parvalbumin is also expressed in a specific population of GABAergic interneurones which are thought to play a role in maintaining the balance between excitation and inhibition in the cortex as well as the hippocampus. In amyotrophic lateral sclerosis (ALS) patents, parvalbumin immunoreactivity is specifically absent from neuron populations lost early in ALS.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Parvalbumin
Applications ELISA, Immunohistochemistry, Western Blot, Immunocytochemistry
Classification Monoclonal
Clone C12
Concentration 1 mg/mL
Conjugate FITC
Formulation PBS, 9.09mM sodium bicarbonate with 640.91mM DMSO, 136.36mM ethanolamine and no preservative; pH 7.4
Gene Pvalb
Gene Accession No. P02625, P20472, P32848
Gene Alias D22S749; HGNC:9704; MGC116759; PALB1; Parv; parvalbumin; Parvalbumin (calcium binding protein); parvalbumin alpha; PV; Pva; PVALB
Gene Symbols Pvalb
Host Species Mouse
Immunogen Synthetic peptide from the full length Rat Parvalbumin protein.
Purification Method Protein A
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 19293, 25269, 5816
Target Species Human, Mouse, Rat
Content And Storage 4°C, store in dark
Product Type Antibody
Form Liquid
Isotype IgG2a
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