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Invitrogen™ PATZ1 Recombinant Rabbit Monoclonal Antibody (6H7A4)
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Catalog No. MA557876
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100 μL
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MA557876 100 μL
MA557875 20 μL
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Catalog No. MA557876 Supplier Invitrogen™ Supplier No. MA557876
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Description

Rabbit Recombinant Monoclonal Antibody

Immunogen sequence: PFPSVASSAP PLTGKRGRGR PRKANLLDSM FGSPGGLREA GILPCGLCGK VFTDANRLRQ HEAQHGVTSL QLGYIDLPPP RLGENGLPIS EDPDGPRKRS R.

The protein encoded by this gene contains an A-T hook DNA binding motif which usually binds to other DNA binding structures to play an important role in chromatin modeling and transcription regulation. Its Poz domain is thought to function as a site for protein-protein interaction and is required for transcriptional repression, and the zinc-fingers comprise the DNA binding domain. Since the encoded protein has typical features of a transcription factor, it is postulated to be a repressor of gene expression. In small round cell sarcoma, this gene is fused to EWS by a small inversion of 22q, then the hybrid is thought to be translocated (t(1;22)(p36. 1;q12). The rearrangement of chromosome 22 involves intron 8 of EWS and exon 1 of this gene creating a chimeric sequence containing the transactivation domain of EWS fused to zinc finger domain of this protein. This is a distinct example of an intra-chromosomal rearrangement of chromosome 22. Four alternatively spliced transcript variants are described for this gene.
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Specifications

Antigen PATZ1
Applications ELISA, Western Blot
Classification Recombinant Monoclonal
Clone 6H7A4
Concentration 1.02 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.05% BSA, 50% glycerol and 0.05% ProClin 300; pH 7.3
Gene PATZ1
Gene Accession No. Q9HBE1
Gene Alias 8430401L15Rik; AI447519; BTB/POZ domain zinc finger transcription factor; BTB-POZ domain zinc finger transcription factor; dJ400N23; Mazr; MAZ-related factor; Patz; PATZ1; POZ (BTB) and AT hook containing zinc finger 1; POZ-, AT hook-, and zinc finger-containing protein 1; POZ/BTB and AT hook containing zinc finger 1; POZ-AT hook-zinc finger protein; protein kinase A RI subunit alpha-associated protein; RIAZ; transcription factor (MAZ-related) MAZR; ZBTB19; Zfp278; zi; Zinc finger and BTB domain-containing protein 19; zinc finger protein 278; Zinc finger sarcoma gene protein; ZNF278; ZSG
Gene Symbols PATZ1
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 250-350 of human PATZ1 (NP_055138.2).
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 23598
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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