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Invitrogen™ PAX2 Polyclonal Antibody
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Catalog No. 716000
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Catalog No. Quantity
71-600-0 100 μg
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Catalog No. 71-600-0 Supplier Invitrogen™ Supplier No. 716000
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Description

Rabbit Polyclonal Antibody

PAX2 Polyclonal Antibody for ELISA, IHC, IP, Western Blot

The pax genes are a family of transcription factors that are active in specific tissues during early embryonic development. Pax family members possess a DNA-binding domain encoded by the paired box. Because paired domain containing genes encode transcription factors, they are capable of executing a genetic program. Several pax genes have also been associated with developmental mutations including: pax-3, which is associated with Waardenburg syndrome, pax-6, which is associated with Aniridia, and pax-2, which is associated with Wilms tumor. During embryogenesis, Pax-2 is expressed in the developing kidney. In particular, the pax-2 gene is expressed in condensing metanephric mesenchyme and in early epithelial structures derived from mesenchyme; however, pax-2 mRNA and protein levels are rapidly down regulated as the tubular epithelium matures. Although Pax-2 is down regulated during renal epithelium maturation, Pax-2 expression persists in the undifferentiated epithelium of Wilms' tumors. Persistent expression of Pax-2 in Wilms' tumors occurs frequently and correlates with the proliferation of poorly differentiated epithelial cells in these tumors. Interestingly, expression of the Wilms' tumor suppresser protein, WT1, coincides with down-regulation of the pax-2 gene; thus, suggesting that WT1 can directly repress pax-2 transcription.
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Specifications

Antigen PAX2
Applications ELISA, Immunohistochemistry, Immunoprecipitation, Western Blot
Classification Polyclonal
Concentration 0.25 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.1% sodium azide; pH 7.4
Gene PAX2
Gene Accession No. P32114, Q02962
Gene Alias FSGS7; Opdc; optic disc coloboma; paired box 2; paired box gene 2; paired box homeotic gene 2; paired box protein Pax-2; PAPRS; PAX2; Pax-2
Gene Symbols PAX2
Host Species Rabbit
Immunogen A GST-Pax-2 fusion protein derived from the C-terminal domain (aa188-385) of the murine Pax-2 protein.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 100422802, 18504, 293992, 5076
Target Species Human, Mouse, Rat, Sheep, Frog, Zebrafish
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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