Invitrogen™ PAX5 Recombinant Rabbit Monoclonal Antibody (RM331)

Rabbit Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA533084

Catalog No. PIMA533084

Description

Specificity: reacts to human Paired box protein Pax-5. It may also react to mouse Paired box protein Pax-5, as predicted by immunogen homology. Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

PAX5 is a member of the paired box (PAX) family of transcription factors. The PAX proteins are important regulators in early development and alterations in the expression of their genes are thought to contribute to neoplastic transformation. PAX5 is the B-cell lineage specific activator protein (BSAP) that is expressed at early, but not late stages, of B-cell differentiation. Its expression has also been detected in developing CNS and testis, therefore, PAX5 may not only play an important role in B-cell differentiation, but also in neural development and spermatogenesis. Mutations in the gene can result in leukemia, acute lymphoblastic 3.

Specifications

• Antigen: PAX5
• Classification: Recombinant Monoclonal
• Concentration: 0.2 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.09% sodium azide
• Gene Accession No.: Q02548
• Gene Symbols: PAX5
• Immunogen: A peptide corresponding to C-terminus of human Paired box protein Pax-5.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Clone: RM331
• Conjugate: Unconjugated
• Gene: PAX5
• Gene Alias: ALL3; B-cell lineage specific activator; B-cell-specific transcription factor; BSAP; EBB-1; KLP; paired box 5; paired box gene 5; paired box gene 5 (B-cell lineage specific activator); paired box homeotic gene 5; paired box protein Pax-5; paired domain gene 5; Pax5; Pax-5; Pax5 variant 1; Pax5 variant 2; RGD1565236; transcription factor PAX 5
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 5079
• Content And Storage: -20°C
• Form: Liquid