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PCNA Rabbit anti-Human, Mouse, Rat, Zebrafish, Polyclonal, Proteintech
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Catalog No. 501726110 Shop All Proteintech Group Inc Products
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50-172-6110 150 μL
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Catalog No. 50-172-6110 Supplier Proteintech Group Inc Supplier No. 102052AP150UL
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Description

Rabbit Polyclonal Antibody

This antibody is a rabbit polyclonal antibody raised against an internal region of human PCNA. The calculated molecular weight of PCNA is 29 kDa, but modified PCNA is 36 kDa.

PCNA (polymerase delta auxiliary protein) is essential for DNA replication and is involved in DNA excision and mismatch repair pathways. PCNA binds to the CDK inhibitor p21, the structure-specific endonucleases Fen1 and XPG, and DNA cytosine 5-methyltransferase (MCMT). PCNA is a potentially useful marker of cells with proliferative potential and for identifying the proliferation status of tumor tissue (i. e. relevant to prognosis). PCNA is a marker for cells in early G1 phase and S phase of the cell cycle. PCNA is found in the nucleus and is a cofactor of DNA polymerase delta, and acts as a homotrimer and helps increase the processing of leading strand synthesis during DNA replication. In response to DNA damage, PCNA is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for PCNA. Pseudogenes of PCNA have been described on chromosome 4 and on the X chromosome.

Specifications

Antigen PCNA
Applications Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation
Classification Polyclonal
Concentration 0.25 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Gene PCNA
Gene Accession No. P04961, P12004, P17918, Q9PTP1
Gene Alias PCNA
Gene Symbols PCNA
Host Species Rabbit
Immunogen PCNA Fusion Protein Ag0277
Purification Method Antigen Affinity Chromatography
Quantity 150 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 18538, 25737, 30678, 5111
Target Species Human, Mouse, Rat, Zebrafish
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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