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Invitrogen™ PCSK2 Polyclonal Antibody
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Catalog No. PA1058
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100 μg
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PA1058 100 μg
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Catalog No. PA1058 Supplier Invitrogen™ Supplier No. PA1058
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Description

Rabbit Polyclonal Antibody

PA1-058 detects prohormone convertase 2 (PC2) from human and mouse alpha pancreas cells. PA1-058 has been successfully used in ICC/IF and Western blot procedures. By Western blot, this antibody detects an ~65 kDa protein representing PC2 from alpha TC 6 cell extract. This antibody is not recommended for Neuro-2a cells in immunfluorescent applications. The PA1-058 immunogen is a synthetic peptide corresponding to residues E(622) L D E A V E R S L Q S I L R K N(638) of mouse PC2. This sequence is completely conserved between mouse and rat protein. PA1-058 synthetic peptide (PEP-138) is available for use in neutralization and control experiments.

The subtilisin-like prohormone convertase (PC) family is a group of cellular enzymes that cleave most prohormones and neuropeptide precursors. Numerous other cellular proteins, some viral proteins, and bacterial toxins that are transported by the constitutive secretory pathway are also targeted for maturation by PCs. PC family members share structural similarities, which include a heterogeneous approximately 10 kDa amino-terminal proregion, a highly conserved approximately 55 kDa subtilisin-like catalytic domain, and carboxyl-terminal domain that is heterogeneous in length and sequence. These enzymes become catalytically active following proregion cleavage within the appropriate cellular compartment. The subcellular localization of PC family members varies. Immunolocalization studies show that PC1 is found in the perinuclear region as well as the trans-Golgi network, whereas PC2 can be found in the trans-Golgi network as well as diffusely distributed in the peripheral cytoplasm.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PCSK2
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 1mg/mL BSA and 0.05% sodium azide
Gene Pcsk2
Gene Accession No. P16519, P21661
Gene Alias 6330411F23Rik; AI839700; EC 3.4.21.94; KEX2-like endoprotease 2; NEC 2; NEC2; Nec-2; Neuroendocrine convertase 2; PC2; PC2-like protein; PCSK2; Phpp-2; Prohormone convertase 2; prohormone convertase 2-like protein; propotein convetase subtilisin/kesin type 2; proprotein convertase 2; proprotein convertase subtilisin/kexin type 2; proprotein convertase type 2; Rpc2; SPC2
Gene Symbols Pcsk2
Host Species Rabbit
Immunogen Synthetic peptide corresponding to residues E(622) L D E A V E R S L Q S I L R K N(638) of mouse PC2.
Purification Method Antigen Affinity Chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 18549, 5126
Target Species Human, Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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