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Invitrogen™ PD-1 (CD279) Chimeric Recombinant Rabbit Monoclonal Antibody (J43)
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Catalog No. PIMA548236
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200 μg
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Catalog No. Quantity
PIMA548236 200 μg
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Catalog No. PIMA548236 Supplier Invitrogen™ Supplier No. MA548236
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Description

Rabbit Recombinant Monoclonal Antibody

Specificity: This antibody is specific for murine PD-1.

Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antig en-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PDL-1 and PDL-2. Upon binding to either of these ligands, signals generated by PD-1 inhibit the activation of the immune response in the absence of danger signals such as LPS or other molecules associated with bacteria or other pathogens. Evidence for this is seen in PD1-null mice who exhibit hyperactivated immune systems and autoimmune diseases. Despite its predicted molecular weight, PD-1 often migrates at higher molecular weight in SDS-PAGE.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PD-1 (CD279) Chimeric
Applications ELISA, Flow Cytometry, Functional Assay, Immunohistochemistry, Immunoprecipitation, Neutralization, Western Blot, Immunocytochemistry
Classification Recombinant Monoclonal
Clone J43
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% ProClin 300
Gene Pdcd1
Gene Accession No. Q02242
Gene Alias CD279; EGK_05005; hPD1; hPD-1; hPD-l; hSLE1; Ly101; mPD-1; PD1; PD-1; Pdc1; Pdcd1; programmed cell death 1; programmed cell death 1 protein; programmed cell death protein 1; programmed cell death protein 1-like; programmed death 1; Protein PD1; protein PD-1; sCD279; SLEB2; soluble CD279; systemic lupus erythematosus susceptibility 2
Gene Symbols Pdcd1
Host Species Rabbit
Immunogen This antibody was raised by immunising Armenian hamsters with B12 cells, a PD-1 cDNA transfectant of BHK cells.
Purification Method Protein A
Quantity 200 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 18566
Target Species Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG λ
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