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Tocris Bioscience™ PD 98059

MEK inhibitor

Manufacturer:  Tocris Bioscience™ 1213/50

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Catalog No. 12-135-0R

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PD 98059 is an inhibitor of mitogen-activated protein kinase kinase (MKK/ MEK). Acts by binding to the inactivated form of MEK, thereby preventing its phosphorylation by cRAF or MEK kinase (IC50 = 2-7 μM). Inhibits cell growth and proliferation in acute myelogenous leukemia (AML) cell lines; causes G1 arrest by blocking p53-dependent p21 induction. Enhances embryonic stem cell self-renewal.


50 mg
M.W. (Observed): 267.28
2-(2-Amino-3-methoxyphenyl)-4 H-1-benzopyran-4-one
Room Temperature
PD 98059
PD 98059
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