Tocris Bioscience™ PD 98059
Manufacturer: Tocris Bioscience™ 1213/50
DescriptionPD 98059 is an inhibitor of mitogen-activated protein kinase kinase (MKK/ MEK). Acts by binding to the inactivated form of MEK, thereby preventing its phosphorylation by cRAF or MEK kinase (IC50 = 2-7 μM). Inhibits cell growth and proliferation in acute myelogenous leukemia (AML) cell lines; causes G1 arrest by blocking p53-dependent p21 induction. Enhances embryonic stem cell self-renewal.
|M.W. (Observed): 267.28|
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For Research Use Only