PD-L1 Monoclonal Antibody (OTI13G7), TrueMAB™, OriGene

Catalog No.	Quantity
50-168-3034	100 μL

Catalog No. 50-168-3034 Supplier OriGene Supplier No. TA809809

Description

Mouse Monoclonal Antibody

PD-L1 (Programmed death receptor ligand 1, B7-H1, CD274) is a 40 kDa transmembrane protein and B7 family member. PD-L1 has been shown to negatively regulate T-cell receptor (TCR) signaling. Upon ligating its receptor, PD-L1 has been reported to decrease TCR-mediated proliferation and cytokine production, and PD-L1 expression was found to be abundant on many murine and human cancers and could be further up-regulated upon IFN-gamma stimulation. Thus, PD-L1 might play an important role in tumor immune evasion. Together with B7.1, PD-L1 can inactivate T cells and this relationship is a focal point of cancer therapeutic treatment. At least two isoforms of PDL-1 are known to exist.

Specifications

• Antigen: PD-L1
• Applications: Flow Cytometry, Immunocytochemistry, Immunofluorescence
• Classification: Monoclonal
• Clone: OTI13G7
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene: CD274
• Gene Accession No.: Q9NZQ7
• Gene Alias: B7-H, B7H1, PD-L1, PDCD1L1, PDCD1LG1, PDL1
• Gene Symbols: CD274
• Host Species: Mouse
• Immunogen: Human recombit protein fragment corresponding to amino acids 19-239 of human PD-L1/CD274 produced in HEK293 cells.
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 29126
• Target Species: Human
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1