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Invitrogen™ PD-L1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA520343

Catalog No. PIPA520343


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Description

Description

This antibody detects human PD-L1 isoform 1 (290aa, 33.3 kDa) and isoform 3 (178aa, 20.5 kDa), as well as mouse and rat PD-L1 (290aa, 33 kDa). It will not cross-react with PD-L2. By Western blot, this antibody has been observed to detect a band at 37 kDa. Recommended positive controls: HeLa cell lysate, Daudi cell lysate, K562 cell lysate, human heart tissue/lysate. PA5-20343 can be used with blocking peptide PEP-0463. The PA5-20343 immunogen is located within amino acids 60-110 of PD-L1.

Programmed death receptor ligand 1 (PD-L1, also called B7-H1) is a recently described B7 family member. To date, one specific receptor has been identified that can be ligated by PD-L1. This receptor, programmed death receptor 1 (PD-1), has been shown to negatively regulate T-cell receptor (TCR) signaling. Upon ligating its receptor, PD-L1 has been reported to decrease TCR-mediated proliferation and cytokine production. PD-L1 expression was found to be abundant on many murine and human cancers and could be further up-regulated upon IFN-gamma stimulation. Thus, PD-L1 might play an important role in tumor immune evasion.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

PD-L1
Polyclonal
Unconjugated
Cd274
A530045L16Rik; B7 homolog 1; B7-H; B7h1; B7-H1; Cd274; CD274 antigen; CD274 molecule; PDCD1 ligand 1; Pdcd1l1; Pdcd1lg1; Pdl1; PD-L1; pdl-1; Programmed cell death 1 ligand 1; programmed death ligand 1; RGD1566211; sCD274; soluble CD274; soluble PD L1; sPD L1
Rabbit
Antigen affinity chromatography
RUO
29126, 499342, 60533
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Liquid
Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
1 mg/mL
PBS with 0.05% sodium azide
Q9EP73, Q9NZQ7
Cd274
A 17 amino acid peptide from near the center of human PDL-1.
100 μg
Primary
Human, Mouse, Rat
Antibody
IgG
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