PD-L1 Recombinant Rabbit Monoclonal Antibody (BLR020E), Bethyl Laboratories

Rabbit Recombit Monoclonal Antibody

Supplier:  Bethyl Laboratories, Inc A700020T

Catalog No. 50-157-1294

Description

The recommended shelf life for this product is 1 year from date of receipt. Application Note: For ICC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE cell sections. For IHC, epitope retrieval with citrate buffer pH 6.0 is recommende

Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antigen-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PDL-1 and PDL-2. PDL-1 is a B7-related protein that inhibits cell-mediated immune responses by reducing the secretion of IL-2 and IL-10 from memory T cells. This suggests that PDL-1 may be useful in reducing allogenic CD4+ memory T-cell responses to endothelial cells, thereby reducing the likelihood of host immune responses to allografts. At least two isoforms of PDL-1 are known to exist; this antibody is specific to the larger isoform. PDL-1 antibody has no cross-reactivity to PDL-2.

Specifications

• Antigen: PD-L1
• Classification: Recombinant Monoclonal
• Conjugate: Unconjugated
• Gene: CD274
• Gene Alias: B7-H, B7H1, PD-L1, PDCD1L1, PDCD1LG1, PDL1, B7 homolog 1, CD274 antigen, PDCD1 ligand 1, programmed cell death 1 ligand 1, programmed death ligand 1
• Host Species: Rabbit
• Purification Method: Purified
• Regulatory Status: RUO
• Gene ID (Entrez): 29126
• Content And Storage: 4° C
• Form: Liquid

• Applications: Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blot
• Clone: BLR020E
• Formulation: BBS with 0.1% BSA and 0.09% sodium azide; pH 8.2
• Gene Accession No.: Q9NZQ7
• Gene Symbols: CD274
• Immunogen: Recombit protein representing the C-terminus of PD-L1
• Quantity: 10 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG