PD-L2 (PDCD1LG2) Mouse anti-Human, Clone: UMAB223, liquid, UltraMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene UM870115

Catalog No. 50-168-5564

Description

CD273 (PDCD1 Ligand 2, Programmed cell death 2 ligand 2, PD-L2, B7-DC) is involved in cell-mediated immune responses initiated by T lymphocytes that are stimulated by cognate peptides bound to MHC molecules on antigen-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as CD273 that mediate inhibitory signals from the APC (antigen presenting cell). CD273 can bind two different but related ligands, PDL-1 and PDL-2, both of which are thought act as a negative regulator of T cell activation. However, it has been suggested that PDL-2 can act to stimulate an immunogenic response through and alternative receptor from PD-1. At least three isoforms of PDL-2 are known to exist; CD273 is specific to the largest isoform. Diseases associated with CD273 include cysticercosis, and myasthenic syndrome.

Specifications

• Antigen: PD-L2 (PDCD1LG2)
• Classification: Monoclonal
• Concentration: 0.5-1.0 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene Accession No.: Q9BQ51
• Gene Symbols: PDCD1LG2
• Immunogen: Full length human recombit protein of human PDCD1LG2 produced in HEK293T cell.
• Quantity: 30 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Flow Cytometry, Immunohistochemistry (Paraffin)
• Clone: UMAB223
• Conjugate: Unconjugated
• Gene: PDCD1LG2
• Gene Alias: B7DC, Btdc, CD273, PD-L2, PDCD1L2, PDL2, bA574F11.2
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 80380
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid