Invitrogen™ PDE8A Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA532979

Catalog No. PIPA532979

Description

Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Dog, Panda, Horse, Rabbit, Pig (100%); Marmoset (94%); Mouse, Rat, Bovine, Elephant, Opossum (88%); Platypus, Zebrafish (81%). For IHC(P), use heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.

Phosphodiesterases (PDEs) regulate the intracellular levels of cAMP and cGMP. These cyclic nucleotides play an important role as second messengers in multiple physiologic processes, including regulation of vascular resistance, cardiac output, visceral motility, immune response, inflammation, neuroplasticity, vision, and reproduction. PDEs comprise a large superfamily of enzymes divided into 10 families. Different PDEs can be distinguished by their structure, tissue expression, localization, substrate specificity, regulation, and sensitivity to PDE inhibitors. Diversity in structure and specificity of function make PDEs promising targets for the pharmacotherapy of diseases modulated by cyclic nucleotide signaling (Hetman et al., 2000).

Specifications

• Antigen: PDE8A
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Pde8a
• Gene Alias: AI551852; cAMP-specific cyclic nucleotide phosphodiesterase 8A; cAMP-specific cyclic nucleotide phosphodiesterase PDE8; FLJ16150; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A; HsT19550; mmPDE8; Pde8; PDE8A; phosphodiesterase 8A; RNPDE8A
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 100068475, 100343099, 100514527, 488752, 5151
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 1 mg/mL
• Formulation: PBS with 0.1% sodium azide
• Gene Accession No.: O60658
• Gene Symbols: Pde8a
• Immunogen: Synthetic 16 amino acid peptide from near N-terminus of human PDE8A.
• Quantity: 50 μg
• Primary or Secondary: Primary
• Target Species: Human, Canine, Rabbit, Pig, Horse
• Product Type: Antibody
• Isotype: IgG