Invitrogen™ PDIA6 Polyclonal Antibody

Catalog No.	Quantity
PA3008	100 μL

Catalog No. PA3008 Supplier Invitrogen™ Supplier No. PA3008

Description

Rabbit Polyclonal Antibody

PA3-008 detects P5 protein in human samples. PA3-008 has successfully been used in Western blot procedures. By Western blot, this antibody detects an ~50 kDa protein representing P5 in human fibrosarcoma HT 1080 cell lysate. The PA3-008 immunogen is a synthetic peptide corresponding to residues D(476) I D L S D V E L D D L G K D E L(492) of human P5. This peptide (Cat. # PEP-224) is available for use in neutralization and control experiments.

P5 is a novel protein that was originally identified in humans. Functionally, P5 has been shown to have peptide binding ability and chaperone activity specific to certain proteins. P5 shares several structural similarities to PDI, an important protein of the ER. The deduced amino acid sequence of P5 shows that it contains the ER retention signal KDEL. P5 also contains two CXXC-like motifs, a motif responsible for oxidoreductase activity. These two CXXC motifs are found on the N- and C-terminus of the protein, one at each end. Studies suggest that the N-terminal CXXC motif is more important than the second for isomerase activity. Contrary to most of the PDI-like proteins, P5 is not stress-inducible.

Specifications

• Antigen: PDIA6
• Applications: Western Blot, Immunocytochemistry
• Classification: Polyclonal
• Concentration: Conc. Not Determined
• Conjugate: Unconjugated
• Formulation: whole serum with 0.01% sodium azide
• Gene: PDIA6
• Gene Accession No.: Q15084
• Gene Alias: 1700015E05Rik; AL023058; C77895; CaBP1; CaBP5; Calcium-binding protein 1; endoplasmic reticulum protein 5; ER protein 5; ERP5; P5; PDIA6; pdi-p5; protein disulfide isomerase A6; protein disulfide isomerase associated 6; protein disulfide isomerase family A member 6; protein disulfide isomerase family A, member 6; protein disulfide isomerase P5; protein disulfide isomerase-associated 6; protein disulfide isomerase-related protein; protein disulfide-isomerase A6; thioredoxin domain containing 7; thioredoxin domain containing 7 (protein disulfide isomerase); thioredoxin domain-containing protein 7; TXNDC7
• Gene Symbols: PDIA6
• Host Species: Rabbit
• Immunogen: Synthetic peptide corresponding to residues D(476) I D L S D V E L D D L G K D E L(492) of human P5.
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 10130
• Target Species: Human
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG