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Invitrogen™ PDPK1 Recombinant Rabbit Monoclonal Antibody (K01_3L55)

Catalog No. MA565857
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MA565857 50 μL
MA564398 100 μL
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Catalog No. MA565857 Supplier Invitrogen™ Supplier No. MA565857
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Description

Rabbit Recombinant Monoclonal Antibody

PDPK1 Recombinant Monoclonal Antibody for Western Blot

PDPK1 (3 Phosphoinositide Dependent Protein Kinase 1) phosphorylates AGC kinases. PDPK1 activates conventional PKC and PKC zeta through phosphorylation of critical threonine residues in the activation loop. PDPK1 also phosphorylates Protein Kinase B (PKB) at threonine 308 in the presence of phosphatidylinositol-3,4,5-trisphosphate. Active Akt inactivates Glycogen Synthase Kinase 3 (GSK3), eventually leading to the dephosphorylation and activation of glycogen synthase, and the stimulation of glycogen synthesis. Because of the role that PDPK1 plays in insulin-induced glycogen synthesis and PKC activation, it is a potentially important target for metabolic drug research.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PDPK1
Applications Western Blot
Classification Recombinant Monoclonal
Clone K01_3L55
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation 50mM tris glycine with 0.05% BSA, 40% glycerol, 150mM NaCl and 0.01% sodium azide; pH 7.4
Gene Pdpk1
Gene Accession No. O15530, O55173, Q9Z2A0
Gene Alias 3-phosphoinositide dependent protein kinase 1; 3-phosphoinositide dependent protein kinase-1; 3-phosphoinositide-dependent protein kinase 1; 3-phosphoinositide-dependent protein kinase 2 pseudogene; HGNC:8809; hPDK1; isoenzyme 1; kinase isoenzyme 1; lipoamide; mPDK1; OTTHUMP00000174525; OTTHUMP00000205076; PDK1; PDPK1; PDPK2; PDPK2P; Pkb kinase; PkB kinase like gene 1; PkB-like 1; PRO0461; Protein kinase B kinase
Gene Symbols Pdpk1
Host Species Rabbit
Immunogen A synthetic peptide of human PDPK1.
Purification Method Protein A/G
Quantity 50 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 18607, 5170, 81745
Target Species Human, Mouse, Rat
Content And Storage Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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