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Cytek Biosciences Inc Antibodies PE Anti-Mouse CD80 (B7-1) (16-10A1) ..... Cat. No. 50-0801-U025 ..... Size 25 µg
Supplier: Cytek Biosciences Inc 500801U025
Antibodies PE Anti-Mouse CD80 (B7-1) (16-10A1) ..... Cat. No. 50-0801-U025 ..... Size 25 µgThe 16-10A1 antibody reacts with mouse CD80, also known as B7-1, a 55 kDa type I transmembrane protein ligand for CD152 (CTLA-4) and for CD28, a co-stimulatory receptor for the T cell receptor (TCR). CD28 also binds a second B7 ligand known as CD86 (B7-2). Both CD80 and CD86 are expressed on activated B cells and antigen-presenting cells. These ligands trigger CD28 signaling in concert with TCR activation to drive T cell proliferation, induce high-level expression of IL-2, impart resistance to apoptosis, and enhance T cell cytotoxicity. The interaction / co-stimulatory signaling between the B7 ligands and CD28 or CTLA-4 provides crucial communication between T cells and B cells or APCs to coordinate the adaptive immune response.
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