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Invitrogen™ Pellino 1 Polyclonal Antibody
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Catalog No. 01676665
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Catalog No. Quantity
01-676-665 200 μL
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Catalog No. 01-676-665 Supplier Invitrogen™ Supplier No. PA141070
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Description

Rabbit Polyclonal Antibody

Suggested positive control: antigen standard for PELI1 (transient overexpression lysate), Ramos or RAW.

The Pellino proteins are a highly homologous family of E3 ubiquitin ligases that act as upstream mediators in Toll-like receptor (TLR) pathways that lead to activation of MAP kinases and transcription factors. Pellino 1 is required for interleukin-1-mediated signaling through its interaction with the IRAK4-IRAK-TRAF6 complex, ultimately resulting in the activation of NF-Kappa-B. Like other members of the Pellino family, Pellino 1 is an E3 ubiquitin ligase, able to catalyze the polyubiquitination of IRAK1. It is activated via phosphorylation by either IRAK1 and IRAK4 or the IKK-related kinases IKK-epsilon; and TBK1. In addition to phosphorylation, Pellino 1 activity is also modulated via ubiquitination and sumoylation.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Pellino 1
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration Conc. Not Determined
Conjugate Unconjugated
Formulation PBS with 0.05% BSA and 0.05% sodium azide
Gene PELI1
Gene Accession No. Q8C669, Q96FA3
Gene Alias 2810468L03Rik; A930031K15Rik; AA409794; AI586297; D11Ertd676e; E3 ubiquitin-protein ligase pellino homolog 1; Peli1; pellino 1; pellino E3 ubiquitin protein ligase 1; pellino homolog 1; pellino1; pellino-1; Pellino-related intracellular-signaling molecule; PRISM; protein pellino homolog 1; RING-type E3 ubiquitin transferase pellino homolog 1
Gene Symbols PELI1
Host Species Rabbit
Immunogen KLH-conjugated synthetic peptide corresponding to a portion of amino acids 100-150 of human Pellino 1 (Peli1).
Quantity 200 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 57162, 67245
Target Species Human, Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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