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PELP1/MNAR Polyclonal Antibody, Bethyl Laboratories

Catalog No. 501557045
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50-155-7045 20 μL
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Catalog No. 50-155-7045 Supplier Bethyl Laboratories, Inc Supplier No. A300180AT
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Description

Rabbit Polyclonal Antibody

The recommended shelf life for this product is 1 year from date of receipt. Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

Coactivator of estrogen receptor-mediated transcription and a corepressor of other nuclear hormone receptors and sequence- specific transcription factors. Plays a role in estrogen receptor (ER) genomic activity when present in the nuclear compartment by activating the ER target genes in a hormonal stimulation dependent manner. Can facilitate ER non-genomic signaling via SRC and PI3K interaction in the cytosol. Plays a role in E2-mediated cell cycle progression by interacting with RB1. May have important functional implications in ER/growth factor cross-talk. Interacts with several growth factor signaling components including EGFR and HRS. Involved in nuclear receptor signaling via its interaction with AR and NR3C1. May promote tumorigenesis via its interaction with and modulation of several oncogenes including SRC, PI3K, STAT3 and EGFR. Plays a role in cancer cell metastasis via its ability to modulate E2-mediated cytoskeleton changes and cell migration via its interaction with SRC and PI3K. Functions as the key stabilizing component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes.

Specifications

Antigen PELP1/MNAR
Applications Immunohistochemistry, Western Blot
Classification Polyclonal
Conjugate Unconjugated
Formulation TBS with 0.1% BSA and 0.09% sodium azide
Gene PELP1
Gene Accession No. Q8IZL8, Q9DBD5
Gene Alias HMX3, MNAR, P160, modulator of non-genomic activity of estrogen receptor; modulator of nongenomic activity of estrogen receptor; proline and glutamic acid rich nuclear protein; proline, glutamic acid and leucine rich protein 1; proline-, glutamic acid- and leucine-rich protein 1; proline-, glutamic acid-, leucine-rich protein 1; transcription factor HMX3
Gene Symbols Pelp1
Host Species Rabbit
Immunogen Between 1000 and 1050
Purification Method Antigen affinity chromatography
Quantity 20 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 27043, 75273
Target Species Human, Mouse
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG
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