Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. Protein Analysis Reagents
  4. Bioactive Small Molecules
  5. 618550

Tocris Bioscience™ Pemetrexed
GREENER_CHOICE

Catalog No. 618550
Click to view available options
Quantity:
50 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

High affinity dihydrofolate reductase inhibitor; also inhibits thymidylate synthase, GARFT and AICART

High affinity dihydrofolate reductase inhibitor (Ki = 7 nM). Also inhibits thymidylate synthase, AICART and glycinamide ribonucleotide formyltransferase (Ki values are 109 nM, and 3.5 μM and 9.3 μM, respectively). Indirectly activates AMPK. Inhibits proliferation of cancer cell lines in vitro.

Chemical Identifiers

CAS 137281-23-3
Molecular Formula C20H21N5O6

Specifications

Quantity 50 mg
Solubility Soluble to 100mM in DMSO
Formula Weight 427.41
Physical Form Solid
Purity >98%
Molecular Weight (g/mol) 427.417
Chemical Name or Material N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid

Safety and Handling

Recommended Storage Store at +4°C
Product Content Correction

Your input is important to us. Please complete this form to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Your feedback has been submitted: Thank you for helping us improve our website.