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Tocris Bioscience™ Pemetrexed
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Catalog No. 618550
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50 mg
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Catalog No. Quantity
61-855-0 50 mg
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Catalog No. 61-855-0 Supplier Tocris Bioscience™ Supplier No. 6185/50
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Description

High affinity dihydrofolate reductase inhibitor; also inhibits thymidylate synthase, GARFT and AICART

High affinity dihydrofolate reductase inhibitor (Ki = 7 nM). Also inhibits thymidylate synthase, AICART and glycinamide ribonucleotide formyltransferase (Ki values are 109 nM, and 3.5 μM and 9.3 μM, respectively). Indirectly activates AMPK. Inhibits proliferation of cancer cell lines in vitro.

Chemical Identifiers

CAS 137281-23-3
Molecular Formula C20H21N5O6

Specifications

Quantity 50 mg
Solubility Soluble to 100mM in DMSO
Formula Weight 427.41
Physical Form Solid
Purity >98%
Molecular Weight (g/mol) 427.417
Chemical Name or Material N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid

Safety and Handling

Recommended Storage Store at +4°C
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