Invitrogen™ Perilipin 1 Polyclonal Antibody, Alexa Fluor™ 647

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA11051A647

Catalog No. PIPA11051A6

Description

PA1-1051 detects perilipin A from rat and 3T3-L1 cell extract. The PA1-1051 immunogen is a synthetic peptide corresponding to the residues C E(502) P I L G R T Q Y S Q L R K K S(517) of rat Perilipin A. This sequence is 93% conserved in humans. The PA1-1051 immunizing peptide (Cat. # PEP-169) is available for use in neutralization and control experiments.

Adipose tissue is an energy reserve in animals and is strictly regulated in nondomestic species. Adipose cells produce and secrete numerous physiologically important proteins, such as lipoprotein lipase (LPL), leptin, adipocyte complement related protein of 30 kDa (Acrp30), resistin, and perilipin. Perilipin is an intracellular neutral lipid droplet protein that is hormonally regulated. This protein is localized exclusively to the surface of lipid droplets. In response to lypotic stimuli, perilipin is phosphorylated by protein kinase A. Once activated, perilipin has inhibitory affects upon hormone-sensitive lipase (HSL), a protein that mediates the hydrolysis of triacylglycerol, the major form of stored energy in the body. Perilipin expression is limited to adipocytes and steroidogenic cells. There are currently two known isoforms, Perilipin A and B. Both of these proteins are encoded by a single-copy gene and are the result of differential splicing events.

Specifications

• Antigen: Perilipin 1
• Classification: Polyclonal
• Conjugate: Alexa Fluor 647
• Gene: Plin1
• Gene Alias: 6030432J05Rik; adipocyte lipid droplet binding protein; FPLD4; Lipid droplet-associated protein; PERI; PERIA; perilipin; perilipin 1; perilipin A; perilipin B; perilipin-1; PLIN; PLIN1
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 103968, 25629
• Content And Storage: 4°C, store in dark, DO NOT FREEZE!
• Form: Liquid

• Applications: Immunocytochemistry
• Concentration: 1.0 mg/mL
• Formulation: PBS with 1.0mg/mL BSA and 0.05% sodium azide
• Gene Accession No.: P43884, Q8CGN5
• Gene Symbols: Plin1
• Immunogen: Synthetic peptide corresponding to the residues C E(502) P I L G R T Q Y S Q L R K K S(517) of rat Perilipin A.
• Quantity: 50 μg
• Primary or Secondary: Primary
• Target Species: Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov