Invitrogen™ Periostin Polyclonal Antibody

Catalog No.	Quantity
PIPA534641	100 μL

Catalog No. PIPA534641 Supplier Invitrogen™ Supplier No. PA534641

Description

Rabbit Polyclonal Antibody

Recommended positive controls: HeLa, A431, H1299, HeLaS3, NIH-3T3. Predicted reactivity: Pig (95%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Periostin (PN), also designated osteoblast-specific factor 2 (OSF-2), is a disulfide linked protein originally isolated as a osteoblast-specific factor. Periostin is a secreted protein that binds heparin and functions as a ligand for alpha(V)beta(3) and alpha(V)beta(5) integrins. In preosteoblasts, Periostin acts as a cell adhesion molecule and plays a role in osteoblast recruitment, spreading and attachment. Periostin is mainly detected in lower gastrointestinal tract, aorta, stomach, placenta, uterus and breast tissues but is up-regulated in epithelial ovarian tumors and overexpressed in breast cancer. Expression of Periostin is increased by bone morphogenetic protein (BMP2) and transforming growth factor beta 1(TGF beta 1). Periostin contains a typical signal sequence, followed by a cysteine-rich domain, a fourfold repeated domain, which shows homology with the insect protein fasciclin, and a C-terminal domain.

Specifications

• Antigen: Periostin
• Applications: Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Classification: Polyclonal
• Concentration: 0.29 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 20% glycerol, 1% BSA and 0.025% ProClin 300, pH 7
• Gene: Postn
• Gene Accession No.: Q15063, Q62009
• Gene Alias: A630052E07Rik; AI747096; fasciclin I-like; Fasciclin-I like; LOW QUALITY PROTEIN: periostin; MGC119510; MGC119511; OSF 2; Osf2; OSF-2; osteoblast specific factor 2; osteoblast specific factor 2 (fasciclin I-like); osteoblast-specific factor 2; PDLPOSTN; peri; periodontal ligament-specific periostin; periostin; periostin variant 1; periostin variant 2; periostin variant 3; periostin variant 4; periostin variant 5; periostin variant 6; periostin variant 7; periostin variant 8; periostin variant 9; periostin, osteoblast specific factor; periostin-like factor; Plf; PN; POSTN; POSTN protein; RP11 412K4.1; RP11-412K4.1
• Gene Symbols: Postn
• Host Species: Rabbit
• Immunogen: Recombinant protein encompassing a sequence within the C-terminus region of human Periostin. The exact sequence is proprietary.
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 10631, 50706
• Target Species: Human, Mouse
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG