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Invitrogen™ PERK Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA582537
Description
Immunogen sequence: NAWLEAPPEK WQEKMDEIWL KDESTDWPLS SPSPMDAPSV KIRRMDPFAT KEHIEIIAPS PQRSRSFSVG ISCDQTSSSE SQFSPLEFSG MDHEDISESV DAAYNLQDSC LTDCDVEDGT MDGNDE.
EIF2AK3 (PERK) is one of 4 kinases that specifically phosphorylate Ser51 of translation initiation factor eIF2-alpha in response to various environmental stresses, leading to a decrease in protein sythesis. In the case of EIF2AK3, signaling is initiated by misfolded proteins in the ER. Defects in EIF2AK3 are the cause of Wolcott-Rallison syndrome (WRS), also known as multiple epiphyseal dysplasia with early-onset diabetes mellitus. WRS is a rare autosomal recessive disorder, characterized by permanent neonatal or early infancy insulin-dependent diabetes and, at a later age, epiphyseal dysplasia, osteoporosis, growth retardation and other multisystem manifestations, such as hepatic and renal dysfunctions, mental retardation and cardiovascular abnormalities.
Specifications
PERK | |
Polyclonal | |
Unconjugated | |
EIF2AK3 | |
2.7.11.1; AI427929; EIF2AK3; eukaryotic translation initiation factor 2 alpha kinase 3; eukaryotic translation initiation factor 2-alpha kinase 3; HsPEK; OTTHUMP00000207187; OTTHUMP00000207188; Pancreatic eIF2-alpha kinase; PEK; Perk; PRKR-like endoplasmic reticulum kinase; WRS | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
9451 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
Immunohistochemistry (Paraffin) | |
0.3 mg/mL | |
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2 | |
Q9NZJ5 | |
EIF2AK3 | |
Recombinant protein corresponding to Human EIF2AK3. Recombinant protein control fragment (Product #RP-90474). | |
100 μL | |
Primary | |
Human | |
Antibody | |
IgG |
Safety and Handling
WARNING: Cancer - www.P65Warnings.ca.gov
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