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Invitrogen™ PERK Polyclonal Antibody
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Catalog No. PIPA582537
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100 μL
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PIPA582537 100 μL
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Catalog No. PIPA582537 Supplier Invitrogen™ Supplier No. PA582537
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: NAWLEAPPEK WQEKMDEIWL KDESTDWPLS SPSPMDAPSV KIRRMDPFAT KEHIEIIAPS PQRSRSFSVG ISCDQTSSSE SQFSPLEFSG MDHEDISESV DAAYNLQDSC LTDCDVEDGT MDGNDE Highest antigen sequence indentity to the following orthologs: Mouse - 88%, Rat - 85%.

EIF2AK3 (PERK) is one of 4 kinases that specifically phosphorylate Ser51 of translation initiation factor eIF2-alpha in response to various environmental stresses, leading to a decrease in protein sythesis. In the case of EIF2AK3, signaling is initiated by misfolded proteins in the ER. Defects in EIF2AK3 are the cause of Wolcott-Rallison syndrome (WRS), also known as multiple epiphyseal dysplasia with early-onset diabetes mellitus. WRS is a rare autosomal recessive disorder, characterized by permanent neonatal or early infancy insulin-dependent diabetes and, at a later age, epiphyseal dysplasia, osteoporosis, growth retardation and other multisystem manifestations, such as hepatic and renal dysfunctions, mental retardation and cardiovascular abnormalities.
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Specifications

Antigen PERK
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.3 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene EIF2AK3
Gene Accession No. Q9NZJ5
Gene Alias 2.7.11.1; AI427929; EIF2AK3; eukaryotic translation initiation factor 2 alpha kinase 3; eukaryotic translation initiation factor 2-alpha kinase 3; HsPEK; OTTHUMP00000207187; OTTHUMP00000207188; Pancreatic eIF2-alpha kinase; PEK; Perk; PRKR-like endoplasmic reticulum kinase; WRS
Gene Symbols EIF2AK3
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human EIF2AK3. Recombinant protein control fragment (Product #RP-90474).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 9451
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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