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Apexbio Technology LLC PF-04620110 1109276-89-2 5mg
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Supplier:  Apexbio Technology LLC A43845

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PF-04620110 (CAS 1109276-89-2) is a selective and orally bioavailable inhibitor of diacylglycerol acyltransferase 1 (DGAT-1) an enzyme that catalyzes the final step in triglyceride biosynthesis Inhibition of DGAT-1 by PF-04620110 has been demonstrated with IC50 values of 19 nM in human cell assays and 8 nM in HT-29 cells The compound exhibits over 100-fold selectivity for DGAT-1 compared to other lipid-metabolizing enzymes including human DGAT-2 ACAT-1 ACAT-2 and various monoacylglycerol acyltransferases PF-04620110 is utilized in biomedical research to study triglyceride metabolism and the physiological roles of DGAT-1

Catalog No. 50-000-94782


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