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  5. Tocris Bioscience™ PF 06281355, >98%

Tocris Bioscience™ PF 06281355, >98%

Catalog No. 600450
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50 mg
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Catalog No. Quantity
60-045-0 50 mg
60-041-0 10 mg
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Catalog No. 60-045-0 Supplier Tocris Bioscience™ Supplier No. 6004/50
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Description

Selective myeloperoxidase (MPO) inhibitor

Selective myeloperoxidase (MPO) inhibitor (IC50 = 1.5 μM in LPS-stimulated human whole blood). Selective for MPO over a panel of 50 receptors, enzymes, ion channels and transporters, including thyroid peroxidase. Inhibits MPO activity in peritoneal lavage and plasma in a murine peritonitis model. Also reduces lung edema in a murine pulmonary immune complex vasculitis model. Orally bioavailable.

Chemical Identifiers

CAS 1435467-38-1
Molecular Formula C14H15N3O4S

Specifications

Quantity 50 mg
Solubility Soluble to 20mM in DMSO with gentle warming
Formula Weight 321.35
Purity >98%
Molecular Weight (g/mol) 321.351
Chemical Name or Material 6-(2,5-Dimethoxyphenyl)-3,4-dihydro-4-oxo-2-thioxo-1(2H)-pyrimidineacetamide

Safety and Handling

Recommended Storage Store at RT
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