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Tocris Bioscience™ PF 06281355, >98%
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Catalog No. 600450
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Quantity:
10 mg
50 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Selective myeloperoxidase (MPO) inhibitor

Selective myeloperoxidase (MPO) inhibitor (IC50 = 1.5 μM in LPS-stimulated human whole blood). Selective for MPO over a panel of 50 receptors, enzymes, ion channels and transporters, including thyroid peroxidase. Inhibits MPO activity in peritoneal lavage and plasma in a murine peritonitis model. Also reduces lung edema in a murine pulmonary immune complex vasculitis model. Orally bioavailable.

Chemical Identifiers

CAS 1435467-38-1
Molecular Formula C14H15N3O4S

Specifications

Quantity 50 mg
Solubility Soluble to 20mM in DMSO with gentle warming
Formula Weight 321.35
Purity >98%
Molecular Weight (g/mol) 321.351
Chemical Name or Material 6-(2,5-Dimethoxyphenyl)-3,4-dihydro-4-oxo-2-thioxo-1(2H)-pyrimidineacetamide

Safety and Handling

Recommended Storage Store at RT
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