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  5. Tocris Bioscience™ PF 06651600 malonate

Tocris Bioscience™ PF 06651600 malonate
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Catalog No. 65065
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25 mg
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Catalog No. Quantity
65-065 5 mg
65-062-5 25 mg
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Catalog No. 65-065 Supplier Tocris Bioscience™ Supplier No. 6506/5
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Description

Potent and selective JAK3 inhibitor

PF 06551600 malonate is a potent and selective JAK3 inhibitor (IC50 = 33.1 μM). Exhibits no significant activity against a panel of other kinases including JAK1, JAK2 and TYK2. Inhibits phosphorylation of STAT5, induced by IL-2, IL-4, IL-7 and IL-15. Suppresses Th1 and Th17 T-cell differentiation and function in vitro. Reduces paw swelling in a rat model of arthritis and reduces disease severity in a rat EAE model.

Specifications

Chemical Name or Material 1-[(2S,5R)-2-Methyl-5-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-1-piperidinyl]-2-propen-1-one malate
CAS 2140301-97-7
Quantity 5 mg
Molecular Formula C15H19N5O.C3H4O4
Purity 98%
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