Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. Chemicals
  4. Organic compounds
  5. Unclassified Organic Compounds
  6. PF 477736, Tocris Bioscience™

PF 477736, Tocris Bioscience™

Catalog No. 427750
Change view
Click to view available options
Quantity:
10 mg
50 mg
2 product options available for selection
Product selection table with 2 available options. Use arrow keys to navigate and Enter or Space to select.
Catalog No. Quantity
42-775-0 50 mg
42-771-0 10 mg
Use arrow keys to navigate between rows. Press Enter or Space to select a product option. 2 options available.
2 options
This item is not returnable. View return policy
Catalog No. 42-775-0 Supplier R&D Systems Supplier No. 4277/50
This item is not returnable. View return policy

Description

Selective Chk1 inhibitor

Selective checkpoint kinase 1 (Chk1) inhibitor (Ki values are 0.49 and 47 nM for Chk1 and Chk2 respectively). Abrogates cell cycle arrest at S and G2-M checkpoints; sensitizes cells to DNA damage. Enhances docetaxel (Cat. No. 4056) efficacy in tumor cells and xenografts.

Chemical Identifiers

CAS 952021-60-2
Molecular Formula C22H25N7O2
Molecular Weight (g/mol) 419.489
InChI Key YFNWWNRZJGMDBR-LJQANCHMSA-N
Synonym unii-xo23pgz0sm, xo23pgz0sm, 2r-2-amino-2-cyclohexyl-n-2-1-methyl-1h-pyrazol-4-yl-6-oxo-5,6-dihydro-1h-1,2 diazepino 4,5,6-cd indol-8-yl-acetamide, r-2-amino-2-cyclohexyl-n-2-1-methyl-1h-pyrazol-4-yl-6-oxo-5,6-dihydro-1h-1,2 diazepino 4,5,6-cd indol-8-yl acetamide, 2r-2-amino-2-cyclohexyl-n-2-1-methylpyrazol-4-yl-9-oxo-3,10,11-triazatricyclo 6.4.1.0?, 1 3 trideca-1,4,6,8 13 ,11-pentaen-6-yl acetamide, d0u9iq, cyclohexaneacetamide, alpha-amino-n-5,6-dihydro-2-1-methyl-1h-pyrazol-4-yl-6-oxo-1h-pyrrolo 4,3,2-ef 2,3 benzodiazepin-8-yl-, alphar, pf hplc, ar-, a-amino-n-5,6-dihydro-2-1-methyl-1h-pyrazol-4-yl-6-oxo-1h-pyrrolo 4,3,2-ef 2,3 benzodiazepin-8-yl cyclohexaneacetamide, 2∼ r-2-azanyl-2-cyclohexyl-∼ n-2-1-methylpyrazol-4-yl-9-oxidanylidene-3,10,11-triazatricyclo 6.4.1.0^ 4,13 trideca-1,4,6,8 13 ,11-pentaen-6-yl ethanamide
PubChem CID 16750408
SMILES CN1C=C(C=N1)C2=NC3=C4C2=CNNC(=O)C4=CC(=C3)NC(=O)C(C5CCCCC5)N

Specifications

Quantity 50 mg
Formula Weight 419.48
Percent Purity >99%
Chemical Name or Material PF 477736

Safety and Handling

Recommended Storage Store at +4°C
Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.