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  5. Tocris Bioscience™ PFI 653

Tocris Bioscience™ PFI 653
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Catalog No. 796350
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Quantity:
10 mg
50 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Potent and selective vanin 1 inhibitor

PFI 653 is a potent and selective vanin 1 inhibitor (IC50 values in the range 6.85 - 24.5 nM). The compound exhibits selectivity over a panel of 40 kinases and a selection of 35 other targets including enzymes, receptors and ion channels (IC50 vs biotinidase >50 μM). Following administration of a single dose of PFI 653 (2 mg/kg iv) in rats AUC is 1790 ng.h/mL, half-life is 1 h and clearance is 19 mL/min/kg. Following oral administration of PFI 653 in solution, bioavailablility is 96%. In mice with DSS-induced inflammatory bowel disease (IBD), oral adminstration of PFI 653 dose-dependently reduces vanin 1 enzyme activity and disease symptoms.

Specifications

Chemical Name or Material 8-Oxa-2-azaspiro[4.5]dec-2-yl[2-[(2-pyrazinylmethyl)amino]-5-pyrimidinyl]methanone
CAS 2173134-00-2
Quantity 50 mg
Target Vanin-1/VNN1
Molecular Formula C18H22N6O2
Purity 0.98
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