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PHIP Rabbit anti-Human, Mouse, Polyclonal, Proteintech
SDP

Catalog No. p-7210075 Shop All Proteintech Group Inc Products
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50-173-3162 150 μL
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Catalog No. 50-173-3162 Supplier Proteintech Group Inc Supplier No. 209331AP150UL
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Description

Rabbit Polyclonal Antibody

PHIP (pleckstrin homology domain interacting protein), also known as ndrp or WDR11, is a 1,821 amino acid protein that contains eight N-terminal WD40 repeats and two bromodomains. It is expressed in skeletal muscle (localizing to the cytosol and nucleus) and primary beta cells (localizing to the nucleus) and acts as a transcriptional activator. PHIP is known to interact with various members of the insulin receptor substrate (IRS) family. The IRS family of proteins mediate insulin receptor signaling and play an important role in insulin-producing beta cell proliferation and survival. PHIP specifically associates with the PH domain of IRS-1 and may function to link IRS-1 to insulin receptors, indicating a vital role of PHIP in the regulation of insulin signaling.

Specifications

Antigen PHIP
Applications Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Western Blot
Classification Polyclonal
Concentration 0.82 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene PHIP
Gene Accession No. Q8VDD9, Q8WWQ0
Gene Alias ndrp, PH interacting protein, PHIP, WDR11
Gene Symbols PHIP
Host Species Rabbit
Immunogen PHIP Fusion Protein Ag14968
Purification Method Antigen Affinity Chromatography
Quantity 150 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 55023, 83946
Target Species Human, Mouse
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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