PHLDA1/TDAG51 Rabbit anti-Human, Polyclonal, Bioss

Catalog No.	Quantity
50-198-3048	100 μL

Catalog No. 50-198-3048 Supplier Bioss Supplier No. BS1364R

Description

Rabbit Polyclonal Antibody

Cytotoxic T lymphocyte (CTL)-mediated cytotoxicity constitutes an important component of specific effector mechanisms in immunosurveillance against virus-infected or -transformed cells. Two mechanisms appear to account for this activity, one of which is the perforin-based process. Independently, a FAS-based mechanism involves the transducing molecule FAS (APO-1) and its ligand (FAS-L). The human FAS (APO-1) protein is a 48 kDa cell surface glycoprotein that belongs to a family of receptors that includes CD40, nerve growth factor receptors and tumor necrosis factor receptors. The FAS antigen is expressed on a broad range of lymphoid cell lines, and is expressed at high levels in T cells subsequent to crosslinking of the T cell receptor (TCR). A previously undescribed protein, TDAG51, restores activation- induced apoptosis in cells that have lost the ability to display Fas in response to activation.

Specifications

• Antigen: PHLDA1/TDAG51
• Applications: Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Concentration: 1 μg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
• Gene: PHLDA1
• Gene Accession No.: Q8WV24
• Gene Alias: Apoptosis-associated nuclear protein; DT1P1B11; PHLDA1; PHRIP; pleckstrin homology like domain family A member 1; Pleckstrin homology-like domain family A member 1; pleckstrin homology-like domain, family A, member 1; PQR protein; PQ-rich protein; Proline- and glutamine-rich protein; Proline- and histidine-rich protein; proline-histidine rich protein; T-cell death associated; T-cell death-associated gene 51 protein; Tdag; Tdag51
• Gene Symbols: PHLDA1
• Host Species: Rabbit
• Immunogen: KLH conjugated synthetic peptide derived from human PHLDA1 .
• Purification Method: Protein A
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 22822
• Target Species: Human
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG