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Invitrogen™ Phosphatidylinositol 3,4,5-trisphosphate Monoclonal Antibody (RC6F8)
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Catalog No. a21328
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A21328 100 μL
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Catalog No. A21328 Supplier Invitrogen™ Supplier No. A21328
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Description

Mouse Monoclonal Antibody

Phosphatidylinositol 3,4,5-trisphosphate Monoclonal Antibody for ICC/IF

Phosphatidylinositol (3, 4, 5)-trisphosphate (PtdIns(3, 4, 5)P3) commonly abbreviated to PIP3 is the product of the class I phosphoinositide 3-kinases (PI 3-kinases) activity on phosphatidylinositol (4, 5)-bisphosphate. PtdIns (3, 4, 5) P3 is dephophosphorylated by the phosphatase, PTEN on the 3 position and by SHIPs (SH2-containing inositol phosphatase) on the 5' position of the inositol ring. The PH domain in a number of proteins binds to PtdIns (3, 4, 5) P3. Such proteins include Akt/PKB, PDK1, Btk1 and ARNO. The generation of PtdIns (3, 4, 5) P3 at the plasma membrane upon the activation of class I PI 3-kinases causes these proteins to translocate to the plasma membrane and accordingly affects their activity. The PH domain allows binding between PtdIns (3, 4, 5) P3 and G-protein coupled receptor kinases (GRKs). This enhances the binding of the GRK to the plasma membrane. [National Center for Biotechnology Information. PubChem Compound Database; CID=53477782].
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Specifications

Antigen Phosphatidylinositol 3,4,5-trisphosphate
Applications Immunocytochemistry
Classification Monoclonal
Clone RC6F8
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.1% BSA and 5mM sodium azide; pH 7.2
Gene Alias C12H24O22P4; phosphatidylinositol 3; phosphatidylinositol-3; PIP3
Host Species Mouse
Immunogen phosphatidylinositol 3,4,5-diphosphate.
Purification Method Purified
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Target Species Chemical
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgM
Target Molecule Chemical
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Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov
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