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Invitrogen™ Phosphatidylinositol 4,5-bisphosphate Monoclonal Antibody (2C11)
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Catalog No. AMS500
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100 μL
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Catalog No. Quantity
AMS500 100 μL
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Catalog No. AMS500 Supplier Invitrogen™ Supplier No. MA3500
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Description

Mouse Monoclonal Antibody

MA3-500 detects PIP2 from human tissues. MA3-500 has been successfully used in ELISA, Immunoprecipitation, Immunofluorescence, and Western blotting procedures. The MA3-500 antigen is liposomes containing synthetic di-palmitoyl ptdlns(4,5)P2.

Phosphatidylinositol 4,5-bisphosphate or PIP2 is an important second messenger for a number of signaling processes. When certain extracellular signals are received, Phosphilipase C cleaves phosphatidylinositol into DAG and PIP2. PIP2 has been shown to interact with actin structural proteins including profiling, gelsolin, and cofilin, and demonstrates regulatory function of actin polymerization. It has also been shown to regulate vesicular transport by interacting with proteins like ADP-ribosylation factor and phospholipase D. PIP2 has also been shown to significantly affect intracellular calcium concentrations, which also regulate a variety of activities.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phosphatidylinositol 4,5-bisphosphate
Applications ELISA, Immunohistochemistry (Paraffin), Immunoprecipitation, Immunocytochemistry
Classification Monoclonal
Clone 2C11
Concentration Conc. Not Determined
Conjugate Unconjugated
Formulation Ascites with 0.05% sodium azide
Gene Alias C45H85O19P3; PIP2
Host Species Mouse
Immunogen Liposomes (prepared in PBS with lipid A, phosphatidylcholine (PC) and cholesterol) containing synthetic di-palmitoyl PtdIns(4,5)P2.
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Target Species Chemical
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgM
Target Molecule Chemical
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