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Invitrogen™ Phospho-4EBP1 (Thr37, Thr46) Polyclonal Antibody
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Catalog No. PIPA577963
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PIPA577963 100 μL
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Catalog No. PIPA577963 Supplier Invitrogen™ Supplier No. PA577963
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Description

Rabbit Polyclonal Antibody

Positive Control: Neuro2A, C8D30, NIH-3T3, Raw264.7, C2C12, PC-12, Rat2, HeLa, 293T (starvation for 24 hr), 293T (starvation for 24 hr and 20%FBS treatment for 0.5 hr) Predicted Reactivity: Zebrafish (100%), Pig (100%), Bovine (100%) Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E, which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-4EBP1 (Thr37, Thr46)
Applications Western Blot
Classification Polyclonal
Concentration 0.12 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 20% glycerol and 0.025% ProClin 300; pH 7
Gene EIF4EBP1
Gene Accession No. Q13541, Q60876, Q62622
Gene Alias 4EBP1; 4E-BP1; AA959816; BP-1; eIF4E-binding protein 1; EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1; eukaryotic translation initiation factor 4E-binding protein 1; MGC431; MGC4316; P/OKCL.6; PHAS-1; PHAS-I; Phosphorylated heat- and acid-stable protein regulated by insulin 1
Gene Symbols EIF4EBP1
Host Species Rabbit
Immunogen Carrier-protein conjugated synthetic peptide surrounding phospho Thr37/Thr46 of human 4E-BP1. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 116636, 13685, 1978
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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