Phospho-AKT (Ser473) Mouse anti-Human, Mouse, Clone: 1C10B8, Proteintech

Mouse Monoclonal Antibody

Supplier:  Proteintech Group Inc 664441IG100UL

Catalog No. 50-173-6870

Description

This antibody detects all the members of AKT with phospho-modification at Ser473.

The Akt family of serine/threonine protein kinases (also called protein kinase B/PKB) plays a key role in insulin signaling, cellular survival, and transformation. Akt1 is activated by phosphorylation on residues threonine 308 and Serine 473. Thr308, in the catalytic domain, is phosphorylated by the protein kinase PDK1, and Ser473, in the COOH-terminal regulatory domain, is phosphorylated by putative serine 473 kinase. To date, a couple of proteins have been shown to physically interact with PKB.

Specifications

• Antigen: Phospho-AKT (Ser473)
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P31749, P31750
• Gene Symbols: AKT1
• Immunogen: Peptide
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG1

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Clone: 1C10B8
• Conjugate: Unconjugated
• Gene: AKT1
• Gene Alias: AKT, AKT1, AKT1-phospho-S473, pakt, p-AKT, Phospho akt, PKB, PKB ALPHA, PRKBA, Protein kinase B, Proto oncogene c Akt, RAC, RAC ALPHA, RAC PK alpha
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 11651, 207
• Content And Storage: -20°C
• Form: Liquid