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Invitrogen™ Phospho-alpha Synuclein (Ser129) Recombinant Rabbit Monoclonal Antibody (J18), APC
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Catalog No. PIMA545930
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100 μg
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PIMA545930 100 μg
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Catalog No. PIMA545930 Supplier Invitrogen™ Supplier No. MA545930
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Description

Rabbit Recombinant Monoclonal Antibody

A 1:500 dilution of MA5-45930 was sufficient for detection of Alpha Synuclein pSer129 in 10 μg of Mouse Brain by ECL immunoblot analysis using Goat Anti-Rabbit IgG:HRP as the secondary antibody. Binds to phosphorylated serine 129 on alpha synuclein. Does not detect unphosphorylated serine 129 alpha synuclein.

Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. These proteins are abundant in the brain and play a role in regulating synaptic transmission and membrane trafficking. Alpha- and beta-synuclein have been shown to selectively inhibit phospholipase D2, suggesting that they may also be involved in signaling pathways. Defects in the SNCA gene, which encodes alpha-synuclein, have been implicated in the pathogenesis of Parkinson's disease. Additionally, alpha-synuclein peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Multiple alternatively spliced transcripts encoding different isoforms have been identified for this gene. Diseases associated with SNCA include Parkinson Disease 1, Autosomal Dominant and Dementia, Lewy Body.
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Specifications

Antigen Phospho-alpha Synuclein (Ser129)
Applications ELISA, Immunohistochemistry, Western Blot, Immunocytochemistry
Classification Recombinant Monoclonal
Clone J18
Concentration 1 mg/mL
Conjugate APC
Formulation 2.48mM MES, 95.64mM phosphate with 0.5M EDTA and no preservative; pH 7.4
Gene SNCA
Gene Accession No. O55042, P37840
Gene Alias Alpha synuclein; alphaSYN; alpha-synuclein; NACP; non A-beta component of AD amyloid; non-A beta component of AD amyloid; non-A4 component of amyloid; Non-A4 component of amyloid precursor; PARK1; PARK4; PD1; Snca; Syn; synuclein alpha; synuclein alpha-140; synuclein, alpha; synuclein, alpha (non A4 component of amyloid precursor)
Gene Symbols SNCA
Host Species Rabbit
Immunogen Human alpha synuclein AA 124-134: AYEMP-pS-EEGYQ-Cys.
Purification Method Affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 20617, 6622
Target Species Human, Mouse
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG
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