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Invitrogen™ Phospho-alpha Synuclein (Ser129) Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA14686
Description
This antibody is predicted to react with bovine, canine, human, mouse and non-human primate based on 100% sequence homology. This antibody is specific for the ~15 kDa alpha-synuclein protein phosophorylated at Ser129. Immunolabeling is blocked by the phosphopeptide used as the antigen but not by the corresponding dephosphopeptide.
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. These proteins are abundant in the brain and play a role in regulating synaptic transmission and membrane trafficking. Alpha- and beta-synuclein have been shown to selectively inhibit phospholipase D2, suggesting that they may also be involved in signaling pathways. Defects in the SNCA gene, which encodes alpha-synuclein, have been implicated in the pathogenesis of Parkinson's disease. Additionally, alpha-synuclein peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Multiple alternatively spliced transcripts encoding different isoforms have been identified for this gene. Diseases associated with SNCA include Parkinson Disease 1, Autosomal Dominant and Dementia, Lewy Body.
Specifications
Phospho-alpha Synuclein (Ser129) | |
Polyclonal | |
Unconjugated | |
SNCA | |
Alpha synuclein; alphaSYN; alpha-synuclein; NACP; non A-beta component of AD amyloid; non-A beta component of AD amyloid; non-A4 component of amyloid; Non-A4 component of amyloid precursor; PARK1; PARK4; PD1; Snca; Syn; synuclein alpha; synuclein alpha-140; synuclein, alpha; synuclein, alpha (non A4 component of amyloid precursor) | |
Rabbit | |
Affinity chromatography | |
RUO | |
20617, 29219, 6622 | |
-20°C, Avoid Freeze/Thaw Cycles | |
Liquid |
Immunohistochemistry, Western Blot | |
0.25 mg/mL | |
0.01M HEPES with 100 μg/mL BSA, 50% glycerol, 0.15M NaCl and no preservative; pH 7.5 | |
O55042, P37377, P37840 | |
SNCA | |
Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser129 of rat SNCA conjugated to KLH. | |
100 μL | |
Primary | |
Human, Mouse, Rat | |
Antibody | |
IgG |
Safety and Handling
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