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Invitrogen™ Phospho-Aurora A (Thr288) Polyclonal Antibody
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Catalog No. 441210G
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44-121-0G 100 μL
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Catalog No. 44-121-0G Supplier Invitrogen™ Supplier No. 441210G
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Description

Rabbit Polyclonal Antibody

Phospho-Aurora A (Thr288) Polyclonal Antibody for ICC/IF, IHC (P), Western Blot

AURKA (Aurora A) is a serine/threonine kinase that regulates mitosis by association in vivo with centrosomes. Overexpression of AURKA is observed in many types of cancer. Aurora A plays a role in cell cycle regulation during anaphase and/or telophase, in relation to the function of the centrosome/spindle pole region during chromosome segregation. Aurora A plays a key role during tumor development and progression and is overexpressed in many human cancers including breast, ovarian and colorectal. Aurora A is viewed as a potential target for anticancer drug treatment. Tissue specificity: Highly expressed in testis and weakly in skeletal muscle, thymus and spleen.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-Aurora A (Thr288)
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Conjugate Unconjugated
Formulation Dulbecco's PBS with 1mg/mL BSA and 0.05% sodium azide; pH 7.3
Gene AURKA
Gene Accession No. O14965, P97477
Gene Alias Aik; Airk; AIRK1; Ark1; ARK-1; AU019385; AURA; AURAK; AURKA; Aurora 2; aurora A; Aurora A Kinase; aurora family kinase 1; Aurora kinase A; aurora/IP; aurora/IPL1-like kinase; aurora/IPL1-related kinase 1; AURORA2; Aurora-A; aurora-related kinase 1; AW539821; Ayk1; Breast tumor-amplified kinase; BTAK; EC 2.7.11.1; hARK1; IAK; IAK1; Ipl1- and aurora-related kinase 1; IPL1-related kinase; MGC34538; OTTHUMP00000031341; OTTHUMP00000166072; PPP1R47; protein phosphatase 1, regulatory subunit 47; ratAurA; RP5-1167H4.6; sereine threonine kinase; serine/threonine kinase 6; serine/threonine protein kinase 15; serine/threonine protein kinase 6; serine/threonine-protein kinase 15; Serine/threonine-protein kinase 6; serine/threonine-protein kinase 6; aurora kinase A; serine/threonine-protein kinase aurora-A; Serine/threonine-protein kinase Ayk1; STK15; STK6; STK7; Unknown (protein for MGC:134472)
Gene Symbols AURKA
Host Species Rabbit
Immunogen The antiserum was produced against a chemically synthesized phosphopeptide derived from the region of human Aurora A Kinase that contains threonine 288. The sequence is highly conserved in mouse and rat.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 20878, 6790
Target Species Human, Mouse
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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