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Phospho-BCKDE1A (Ser293) Polyclonal Antibody, Bethyl Laboratories

Catalog No. p-7143051
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50-156-8355 20 μL
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Catalog No. 50-156-8355 Supplier Bethyl Laboratories, Inc Supplier No. A304672AT
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Description

Rabbit Polyclonal Antibody

The recommended shelf life for this product is 1 year from date of receipt. Based on 100% sequence identity, this antibody is predicted to react with Human, Rat, Bovine and Chimpanzee

The BCKDHA gene encodes the E1-alpha subunit of the branched-chain alpha-keto acid (BCAA) dehydrogenase complex (BCKD; EC 1.2.4.4), an inner-mitochondrial enzyme complex that catalyzes the oxidative decarboxylation of the branched-chain alpha-ketoacids derived from isoleucine, leucine, and valine. This reaction is the second major step in the catabolism of the branched-chain amino acids (Wynn et al., 1998 [PubMed 9582350]). The BCKD complex consists of 3 catalytic components: a heterotetrameric (alpha2-beta2) branched-chain alpha-keto acid decarboxylase (E1), a homo-24-meric dihydrolipoyl transacylase (E2; MIM 248610), and a homodimeric dihydrolipoamide dehydrogenase (E3; MIM 238331). E1 is a thiamine pyrophosphate (TPP)-dependent enzyme. The reaction is irreversible and constitutes the first committed step in BCAA oxidation. The BCKDHB gene (MIM 248611) encodes the beta subunit of E1. The complex also contains 2 regulatory enzymes, a kinase and a phosphorylase.

Specifications

Antigen Phospho-BCKDE1A (Ser293)
Applications Western Blot
Classification Polyclonal
Conjugate Unconjugated
Formulation TBS with 0.1% BSA and 0.09% sodium azide
Gene Bckdha
Gene Accession No. P50136
Gene Alias BCKDE1A, MSU, MSUD1, OVD1A, 2-oxoisovalerate dehydrogenase (lipoamide), 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial, BCKDH E1-alpha, branched-chain alpha-keto acid dehydrogenase E1 component alpha chain
Gene Symbols Bckdha
Host Species Rabbit
Immunogen Surrounding serine 293
Purification Method Antigen affinity chromatography
Quantity 20 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 12039
Target Species Mouse
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG
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