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Invitrogen™ Phospho-Bim (Ser69) Monoclonal Antibody (K.724.4)
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Catalog No. PIMA514814
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100 μL
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PIMA514814 100 μL
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Catalog No. PIMA514814 Supplier Invitrogen™ Supplier No. MA514814
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Description

Rabbit Monoclonal Antibody

It is not recommended to aliquot this antibody.

BIM belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family, including BCL2, BCL2L1/BCL-X(L), and MCL1, and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-Bim (Ser69)
Applications Immunoprecipitation, Western Blot
Classification Monoclonal
Clone K.724.4
Concentration 185 μg/mL
Conjugate Unconjugated
Formulation 0.01M HEPES with 100μg/mL BSA, 50% glycerol, 0.15M NaCl and <0.02% sodium azide; pH 7.5
Gene BCL2L11
Gene Accession No. O43521, O54918
Gene Alias 1500006F24Rik; BAM; Bcl2 interacting mediator of cell death; bcl-2 interacting mediator of cell death; bcl-2 interacting protein Bim; BCL2 like 11; Bcl-2 like 11; Bcl-2 related apoptotic gene product BimL; bcl2-interacting mediator of cell death; BCL2L11; Bcl2-L-11; BCL2-like 11 (apoptosis facilitator); bcl-2-like protein 11; bcl-2-like protein 11-like; bcl-2-related ovarian death agonist; bcl-2-related ovarian death protein; BIM; Bim EL; Bim-A; BIM-alpha6; BIM-beta6; BIM-beta7; BIMEL; BimEL protein; BimL; BOD; OTTHUMP00000197013; OTTHUMP00000204247; Unknown (protein for MGC:134444)
Gene Symbols BCL2L11
Host Species Rabbit
Immunogen Synthetic phosphopeptide corresponding to residues surrounding pSer69 of human Bim protein.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 10018, 12125
Target Species Human, Mouse
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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