Invitrogen™ Phospho-Calmodulin 1/2/3 (Thr80, Ser82) Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5104932

Catalog No. PIPA5104932

Description

Antibody detects endogenous levels of Calmodulin1/2/3 only when phosphorylated at Thr80 + Ser82, which site historically referenced as Thr79+Ser81.

Calmodulin is a small, highly conserved calcium binding protein found in all eukaryotic cells. With the capacity to bind up to four calcium ions, this 17 kDa protein acts as an important intracellular receptor for regulatory calcium signals. As it binds calcium, calmodulin undergoes conformational changes which can increase its affinity for target proteins. It acts both directly, through interaction with key target enzymes, and indirectly, via specific kinases. Studies have found that calmodulin participates in the regulation of several biological processes including energy and biosynthetic metabolism, cell motility, exocytosis, cytoskeletal assembly, and intracellular modulation of both cAMP and calcium concentrations.

Specifications

• Antigen: Phospho-Calmodulin 1/2/3 (Thr80, Ser82)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CALM1
• Gene Alias: 1500001E21Rik; AI256814; AI327027; AI461935; AL024000; AL024017; Calm; CALM1; Calm2; CALM3; CALML2; calmodulin; calmodulin 1; Calmodulin 1 (phosphorylase kinase, delta); calmodulin 2; calmodulin 2 (phosphorylase kinase, delta); calmodulin 3; calmodulin 3 (phosphorylase kinase, delta); Calmodulin III; Calmodulin-1; Calmodulin-2; Calmodulin-3; Cam; CAM1; Cam2; CAM3; CaMA; CAMB; CAMC; CAMI; CAMII; CAMIII; CPVT4; DD132; epididymis secretory protein Li 72; HEL-S-72; LP7057 protein; LQT14; LQT15; PHKD; PHKD2; PHKD3; phosphorylase kinase delta; phosphorylase kinase subunit delta; phosphorylase kinase, delta subunit; prepro-calmodulin 1; prepro-calmodulin 2; prepro-calmodulin 3; R75142; RNCAMIII
• Host Species: Rabbit
• Purification Method: sequential chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 12313, 12314, 12315, 24242, 24244, 50663, 801, 805, 808
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: P0DP23, P0DP24, P0DP25, P0DP26, P0DP27, P0DP28, P0DP29, P0DP30, P0DP31
• Gene Symbols: CALM1, CALM2, CALM3
• Immunogen: A synthesized peptide derived from human CALM1(Accession P0DP23), corresponding to amino acid residues around phosphorylated Ser82.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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