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Invitrogen™ Phospho-CAMKIV (Thr200) Polyclonal Antibody
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Catalog No. PIPA5105011
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PIPA5105011 100 μL
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Catalog No. PIPA5105011 Supplier Invitrogen™ Supplier No. PA5105011
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of CaMK4 only when phosphorylated at Threonine 200.

CAMK4 (CaMKIV) is a serine/threonine protein kinase that phosphoryates CREB, oncoprotein 18, and SRF. It has limited tissue distribution, and has been implicated in transcriptional regulation in lymphocytes, neurons and male germ cells. The nuclear localization of this protein is consistent with its role in mediating calcium-dependent gene expression. CaMKIV is particularly abundant in testis, T-cells, and neurons but is also found in other tissues to varying degrees. In neurons, CaMKIV is thought to play an important role in synaptic plasticity via its gene regulatory effects. In T-cells, this protein plays an important role in calcium signaling which could affect the transcription regulatory protein, nuclear factor of activated T-cells (NFAT). CaMKIV is encoded, along with calspermin, by the CaMKIV gene. It has been found that, in testes, CaMKIV is expressed in germ cells and found to be associated with chromatin. The association of CaMKIV with chromatin suggests a potential role in chromatin remodeling during nuclear condensation in spermatids.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-CAMKIV (Thr200)
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene CAMK4
Gene Accession No. P08414, P13234, Q16566
Gene Alias A430110E23Rik; AI666733; brain Ca(2+)-calmodulin-dependent protein kinase type IV; brain Ca++-calmodulin-dependent protein kinase type IV; Ca2+/calmodulin-dependent protein kinase type IV/Gr; Calcium/calmoduli; calcium/calmodulin dependent protein kinase IV; calcium/calmodulin-dependent protein kinase IV; calcium/calmodulin-dependent protein kinase IV L homeolog; calcium/calmodulin-dependent protein kinase type IV; calcium/calmodulin-dependent protein kinase type IV catalytic chain; Calmodulin-dependent protein kinase IV; calspermin; CAM kinase- GR; CAM kinase IV; CAM kinase-GR; CAMK; CaMK IV; camk4; camk4.L; camk4-A; CAMK-GR; CAMKIV; CaMKIV/Gr; Ccdpk; D18Bwg0362e; EC 2.7.11.17; KCC4; kinase CaMK4; OTTHUMP00000222818; RATCCDPK; xCaM; XELAEV_18008011mg
Gene Symbols CAMK4
Host Species Rabbit
Immunogen A synthesized peptide derived from human CAMK4(Accession Q16566), corresponding to amino acid residues around phosphorylated Thr200.
Purification Method Sequential chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 12326, 25050, 814
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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