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Phospho-CDKN1B (Thr198) Rabbit anti-Human, Polyclonal, Bioss
SDP

Catalog No. 501986458
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50-198-6458 100 μL
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Catalog No. 50-198-6458 Supplier Bioss Supplier No. BS5279R
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Description

Rabbit Polyclonal Antibody

p27 Kip1 functions as a negative regulator of G1 mouse expression and has been proposed to function as a possible mediator of TGFb induced G1 arrest. p27 Kip1 is an important regulator of cell cycle progression, a potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. p27 Kip1 forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. p27 Kip1 acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry. p27 Kip1 has a molecular weight of approximately 27kDa and the degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state.

Specifications

Antigen Phospho-CDKN1B (Thr198)
Applications Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 μg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene Cdkn1b
Gene Accession No. P46527
Gene Alias AA408329; AI843786; Cdki1b; CDKN1B; CDKN4; CDN1B; cyclin dependent kinase inhibitor 1B; Cyclin-dependent kinase inhibitor 1B; Cyclin-dependent kinase inhibitor 1B (p27 Kip1); cyclin-dependent kinase inhibitor 1B (p27, Kip1); Cyclin-dependent kinase inhibitor p27; cyclin-dependent kinase inhibitor p27/Kip1; KIP1; MEN1B; MEN4; p27; P27 CDKN1B; p27(KIP1); p27Kip1; putative cyclin-dependent kinase inhibitor p27
Gene Symbols Cdkn1b
Host Species Rabbit
Immunogen KLH conjugated synthetic phosphopeptide derived from human CDKN1B/P27kip1 around the phosphorylation site of Thr198 [RRQ (p-T)].
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1027
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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