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Phospho-CHK2 (Thr68) Rabbit anti-Human, Polyclonal, Bioss
SDP

Catalog No. 501985605
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50-198-5605 100 μL
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Catalog No. 50-198-5605 Supplier Bioss Supplier No. BS3721R
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Description

Rabbit Polyclonal Antibody

Checkpoint kinase 2 (Chk2) is a serine/threonine-protein kinase which functions as a cell cycle checkpoint regulator. ATM and ATR kinases are activated in response to ionizing and ultraviolet radition, and phosphorylate Thr68 and other sites in the amino-terminal region of Chk2 dimerisation and activation. Activated Chk2 phosphorylates and inhibits Cdc25C phosphates, preventing the entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, Chk2 can phosphorylate BRCA1, allowing BRCA1 to restore survival after DNA damage. Chk2 is a putative tumor suppressor protein, with mutations in to the Chk2 gene linked to Li-Fraumeni syndrome, a familiar cancer usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors.

Specifications

Antigen Phospho-CHK2 (Thr68)
Applications Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 μg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene Chek2
Gene Accession No. O96017
Gene Alias CDS1; Cds1 homolog; Checkpoint kinase 2; checkpoint-like protein CHK2; Chek2; CHK2; Chk2 (phospho T68); Chk2 (pThr68); CHK2 checkpoint homolog; Chk2 phospho; Chk2 phospho T68; del9; EC 2.7.11.1; hCds1; Hucds1; kinase Chk2; LFS2; OTTHUMP00000199044; OTTHUMP00000199045; OTTHUMP00000199064; OTTHUMP00000199115; OTTHUMP00000199116; phospho Chk2 (T68); phospho Thr68 Chk2; PP1425; protein kinase Chk2; RAD53; Rad53 homolog; RP11-436C9.1; Serine/threonine-protein kinase Chk2
Gene Symbols Chek2
Host Species Rabbit
Immunogen KLH conjugated synthetic phosphopeptide derived from human CHK2 around the phosphorylation site of Thr68.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 11200
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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