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Invitrogen™ Phospho-CPI-17 (Thr38) Polyclonal Antibody
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Catalog No. PIPA5105024
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PIPA5105024 100 μL
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Catalog No. PIPA5105024 Supplier Invitrogen™ Supplier No. PA5105024
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of CPI17alpha only when phosphorylated at Threonine 38.

CPI-17 is a phosphorylation-dependent inhibitory protein for smooth muscle myosin phosphate. CPI-17 was originally identified as a PKC-potentiated inhibitory protein of protein phosphatase-1, which is dominantly expressed in smooth muscle. Phosphorylation at Threonine 38, in vitro, by PKC or Rho-kinase enhances the inhibitory potency toward myosin phosphatase. CPI-17 is also phosphorylated at Threonine 38 by protein kinase N and might be involved in the calcium sensitization of smooth muscle contraction as a downstream effector of Rho and/or arachidonic acid. CPI-17 is dually phosphorylated at Serine 12 and Threonine 38 by a MYPT-associated kinase, M110 kinase.
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Specifications

Antigen Phospho-CPI-17 (Thr38)
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene PPP1R14A
Gene Accession No. Q91VC7, Q96A00, Q99MC0
Gene Alias 1110001M11Rik; 17 kDa PKC-potentiated inhibitory protein of PP1; 17-kDa PKC-potentiated inhibitory protein of PP1; 17-KDa protein; Cpi; CPI17; CPI-17; PKC-potentiated inhibitory protein of PP1; PPP1INL; PPP1R14A; Protein kinase C-potentiated inhibitor protein of 17 kDa; protein phosphatase 1 regulatory inhibitor subunit 14A; protein phosphatase 1 regulatory subunit 14A; protein phosphatase 1, regulatory (inhibitor) subunit 14A
Gene Symbols PPP1R14A
Host Species Rabbit
Immunogen A synthesized peptide derived from human PPP1R14A(Accession Q96A00), corresponding to amino acid residues around phosphorylated Thr38.
Purification Method Sequential Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 114004, 68458, 94274
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

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