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  6. Invitrogen™ Phospho-CREB (Ser133) Recombinant Rabbit Monoclonal Antibody (CREBS133-4D11), FITC, Invitrogen™

Invitrogen™ Phospho-CREB (Ser133) Recombinant Rabbit Monoclonal Antibody (CREBS133-4D11), FITC, Invitrogen™
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Catalog No. PIMA536991
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100 Tests
Catalog No. Quantity
PIMA536991 100 Tests
PIMA537273 10 Tests
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Catalog No. PIMA536991

Supplier: Invitrogen™ MA536991

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Description

Rabbit Recombinant Monoclonal Antibody

CREB (Cyclic AMP response element binding protein) is a 43 kDa basic/leucine zipper transcription factor that binds the cyclic AMP response element (CRE) and activates transcription in response to a variety of extracellular signals including neurotransmitters, hormones, membrane depolarization, and growth and neurotrophic factors. Activation of CREB is dependent upon the phosphorylation of serine 133. Phosphorylation of CREB occurs via p44/42 MAP kinase and p90RSK, and via p38 MAP kinase and MSK1. Although CREB will bind DNA independent of its phosphorylation state, only the phosphorylated form is competent as a transcription factor. CREB binding protein (CBP), a transcriptional coactivator that directly interacts with CREB, binds to CREB in the region of serine 133. CREB is involved in different cellular processes including the synchronization of circadian rhythmicity, differentiation of adipose cells, and learning and memory. In humans, the gene is located on the q arm of chromosome 2. Diseases associated with CREB dysfunction include Alzheimer's Disease, histiocytoma and soft tissue melanoma.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-CREB (Ser133)
Applications Flow Cytometry
Classification Recombinant Monoclonal
Clone CREBS133-4D11
Conjugate FITC
Formulation PBS with 0.20% BSA and 0.09% sodium azide
Gene CREB1
Gene Accession No. P16220, Q01147
Gene Alias 2310001E10Rik; 3526402H21Rik; active transcription factor CREB; AV083133; cAMP response element binding protein 1; cAMP responsive element binding protein 1; cAMP-response element-binding protein-1; cAMP-responsive element-binding protein 1; CREB; CREB1; Creb-1; cyclic adenosine 3',5'-monophosphate response element-binding protein CREB; cyclic AMP-responsive element-binding protein 1; htCREB; MGC9284; OTTHUMP00000206661; OTTHUMP00000206662; OTTHUMP00000206667; transactivator protein; Y protein
Gene Symbols CREB1, CrebB
Host Species Rabbit
Immunogen A synthetic phospho-peptide corresponding to residues surrounding Ser133 of human phospho CREB.
Purification Method Protein A/G
Quantity 100 Tests
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 12912, 1385
Target Species Human, Mouse
Content And Storage 4°C, store in dark
Product Type Antibody
Form Liquid
Isotype IgG κ
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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