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Invitrogen™ Phospho-Cyclin D3 (Thr283) Polyclonal Antibody
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Catalog No. PIPA5104862
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PIPA5104862 100 μL
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Catalog No. PIPA5104862 Supplier Invitrogen™ Supplier No. PA5104862
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of Cyclin D3 only when phosphorylated at Threonine 283.

The protein encoded by this gene belongs to the highly conservedcyclinfamily, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle.Cyclins function as regulators of CDK kinases. Differentcyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. Thiscyclinforms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. The CDK4 activity associated with thiscyclinwas reported to be necessary for cell cycle progression through G2 phase into mitosis after UV radiation. Several transcript variants encoding different isoforms have been found for this gene. Diseases associated with CCND3 include Retinoblastoma and Plasma Cell Leukemia.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-Cyclin D3 (Thr283)
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene CCND3
Gene Accession No. P30281, P30282, P48961
Gene Alias 9230106B05Rik; AA682053; AL024085; AW146355; C78795; CCND 3; Ccnd3; CGD3; cyclin D3; CyclinD3; Cyl-3; D3 type cyclin; D3-type cyclin; G1/S-specific cyclin-D3; OTTHUMP00000223415; RP5-973N23.3
Gene Symbols CCND3
Host Species Rabbit
Immunogen A synthesized peptide derived from human CCND3(Accession P30281), corresponding to amino acid residues around phosphorylated Thr283.
Purification Method Sequential Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 12445, 25193, 896
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

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