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Invitrogen™ Phospho-E2F1 (Thr433) Polyclonal Antibody
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Catalog No. PIPA5104949
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PIPA5104949 100 μL
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Catalog No. PIPA5104949 Supplier Invitrogen™ Supplier No. PA5104949
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of E2F1 only when phosphorylated at Threonine 433.

The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-E2F1 (Thr433)
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene E2F1
Gene Accession No. Q01094, Q61501
Gene Alias E2F transcription factor 1; E2F1; E2F-1; mKIAA4009; PBR3; PRB-binding protein E2F-1; RBAP1; RBAP-1; RBBP3; RBBP-3; RBP3; Retinoblastoma-associated protein 1; retinoblastoma-binding protein 3; Transcription factor E2F1
Gene Symbols E2F1
Host Species Rabbit
Immunogen A synthesized peptide derived from human E2F1(Accession Q01094), corresponding to amino acid residues around phosphorylated Thr433.
Purification Method Sequential chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 13555, 1869
Target Species Human, Mouse
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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